2012年度

原著論文

Seko, Y., Azuma, N., Kaneda, M., Nakatani, K., Miyagawa, Y., Noshiro, Y., Kurokawa, R., Okano, H., Umezawa, A. Derivation of human differential photoreceptor-like cells from the iris by defined combinations of CRX, RX and NEUROD. Plos One, 7: 1-11(e35611), 2012.

2013年度

原著論文

Wada-Kiyama, Y., Suzuki, C., Hamada, T., Rai, D., Kiyama, R., Kaneda, M., Sakuma, Y. Estrogen-induced signaling in the sexually dimorphic nucleus of the rat preoptic area: potential involvement of cofilin in actin dynamics for cell migration. Biochem. Biophys. Res. Cummun., 434: 287-292, 2013.

Homma, K., Okamoto, S., Mandai, M., Gotoh, N., Rajasimha, H.K., Chang, Y.-S., Chen, S., li, W., Cogliati, T., Swaroop, A., Takahashi, M.. Developing rods transplanted into the degenerating retina of Crx-knockout mice exhibit neural activity similar to native photoreceptors. Stem Cells, 31: 1149-1159, 2013.

Rai, D., Ishii, T., Imada, H., Wada-Kiyama, Y., Kiyama, R., Miyachi, E., Kaneda, M. Distribution and development of P2Y1-purinoceptors in the mouse retina. J. Mol. Histol., 44: 639-644, 2013.

総説

Kaneda, M. Signal processing in the mammalian retina. J. Nippon Med. Sch., 80:16-24, 2013.

2014年度

原著

Seko, Y., Azuma, N., Ishii, T., Komuta, Y., Miyamoto, K., Miyagawa, Y., Kaneda, M., Umezawa, A. Derivation of human differential photoreceptor cells from adult human dermal fibloblasts by defined combinations of CRX, RAX, OTX2 and NEUROD. Genes Cells, 19: 198-208, 2014.

Ishii, T., Kaneda, M. ON-pathway-dominant glycinergic regulation of cholinergic amacrine cells in the mouse retina. J. Physiol. (Lond.), 592: 4235-4245, 2014.

Kiyama, R., Zhu, Y., Kawaguchi, K., Iitake, N., Wada-Kiyama, Y. Estrogen-responsive genes for environmental studies. Environmental Technology & Innovation, 1-2: 16-28, 2014.

総説

石井 俊行、世古 裕子、金田 誠 再生医学とパッチクランプ法 日本医科大学医学会雑誌 10: 4-5, 2014.

2015年度

原著

Ishii, T., Iwasawa, S., Kurimoto, R., Maeda, A., Takiguchi, Y., Kaneda, M. Crizotinib-induced abnormal signal processing in the retina. Plos One, 10: e0135521, 2015.

Kaewkhaw, R., Kaya, K.D., Brooks, M., Homma, K., Zou, J., Chaitankar, V., Rao, M., Swaroop, A. Transcriptome dynamics of developing photoreceptors in three-dimentional retina cultures recapitulates temporal sequence of human cone and rod differentiation revealing cell surface markers and gene networks. Stem Cells, 1002/stem 2122, 2015.

Hama, H., Hioki, H., Namiki, K., Hoshida, T., Kurokawa, H., Ishidate, F., Kaneko, T., Akagi, T., Saito, T., Saido, T., Miyawaki, A. ScaleS: an optical clearing palette for biological imaging. Nat. Neurosci., 18: 1518-29, 2015.

Esaki, K., sayano, T., Sonoda, C., Akagi, T., Suzuki, T., Ogawa, T., Okamoto, M., Yoshikawa, T., Hirabayashi, Y., Furuya, S. L-serine deficiency elicits intracellular accumulation of cytotoxic deoxyshingolipids and lipid body formation. J. Biol. Chem., 290: 14595-14609, 2015.

Kino, Y., Washizu, C., Kurosawa, M., Yamada, M., Miyazaki, H., Akagi, T., Hashikawa, T., Doi, H., Takumi, T., Hicks, G.G., Hattori, N., Shimogori, T., Nukina, N. FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis. Acta Neuropathologica Communications, 3: 24, 2015 DOI 10.1186/s40478-015-0202-6.

総説

Kiyama, R., Wada-Kiyama, Y. Estrogenic endocrine disruptors: molecular mechanism of action. Environment International, 83: 11-40, 2015.

2016年度

原著

Komuta, Y., Ishii, T., Kaneda, M., Ueda, Y., Miyamoto, K., Toyoda, M., Umezawa, A., Seko, Y. In vitro transdifferentiation of human peripheral blood mononuclear cells to photoreceptor-like cells. Biology Open, 2016, DOI 10:1242/bio.016477.


Oikawa, S., Kai, Y., Tsuda, M., Ohata, H., Mano, A., Mizoguchi, N., Sugama, S., Nemoto, T., Suzuki, K., Kurabayashi, A., Muramoto, K., Kaneda, M., Kakinuma, Y. Non-neuronal cardiac cholinergic system influences CNS via the vagus nerve to acquire a stress refractory propensity. Clinical Science, 130: 1913-28, 2016. DOI:10.1042/CS20160277.

2017年度

原著

Ichinohe S., Ishii T., Takahashi H., Kaneda M. Physiological contribution of P2X receptors in postreceptoral signal processing in the mouse retina. Neurosci. Res., 115: 5-12, 2017.


Homma K., Usui S., and Kaneda M. Knock-in strategy at 3’-end of Crx gene by CRISPR/Cas9 system reveals the gene expression profiles during human photoreceptor differentiation. Genes Cells, 22: 250-264, 2017.


Ishii T., Homma K., Mano A., Akagi T., Shigematsu Y., Shimoda Y., Inoue H., Kakinuma Y., Kaneda M. Novel channel-mediated choline transport in cholinergic neurons of the mouse retina. J. Neurophysiol., 118: 1952-1961, 2017.


Kimura, T., Suzuki, M., Akagi, T. Age-dependent changes in synaptic plasticity enhance tau oligomerization in the mouse hippocampus. Acta Neuropathol. Commun., 5: 67, 2017, DOI: 10. 1186/s40478-017-0469-x


Hayashi, K., Furuya, A., Sakamaki, Y., Akagi, T., Shinoda, Y., Sadakata, T., hashikawa, T., Shimizu, K., Minami, H., Sano, Y., Nakayama, M., Furuichi, T. The brain-specific RasGEF very-KIDN is required for normal dendritic growth in cerebellar granule cells and proper motor coordination. PloS One, 2017, DOI: 10, 1371/journal.pone.0173175.


Yamagata, T., Ogiwara, I., Mazaki, E., Yanagawa, Y., Yamakawa, K. Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2. Biomed. Biophys. Res. Commun., 491: 1070-1076, 2017.


Hedrick, T.P., Nobis, W.P., Foote, K.M., Ishii, T., Chetkovich, D.M., Swanson, G.T. Excitatory synaptic input to hilar mossy cells under basal and hyperexcitacble conditions. eNeuro, 4: e0364-17, 2017.


2018年度

Tatsukawa, T., ogiwara, I., Mazaki, E., Shimohata, A., Yamakawa, K. Impairments in social novelty recognition and spatial memory in mice with conditional deletion of Scn1a in parvalbumin-expressing cells. Neurobiol. Dis., 112: 24-34, 2018.


Xu, D., Robinson, A.P., Ishii, T., Duncan, D.S., Alden, T.D., Goings, G.E., Ifergan, I., Podojil, J.R., Penaloza-Macmaster, P., Kearney, J.A., Swanson, G.T., Miller, S.D., Koh, S. Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy. J. Exp. Med., 2018, DOI: 10.1084/jem.20171285.


Ishii, T., Yin, C., Seko, Y., Umezawa, A., Kaneda, M. Variation in the phenotype of photosensitive cells produced from human fibroblast cell lines. J. Nippon Med. Sch., 85: 110-116, 2018.


Ohkuma, M., Kaneda, M., Yoshida, S., Fukuda, A., Miyachi, E. Optical measurement of glutamate in slice preparations of the mouse retina. Neurosci. Res. 2018, in press.


Middleton, S J., Kneller, E M., Chen, S., Ogiwara, I., Montal, M., Yamagata, K., McHugh, T J. Altered hippocampal replay is associated with memory impairment in mice heterozygous for the Scn2a gene. Nature Neuroscience., 21: 996-1003, 2018.


Ogiwara, I., Miyamoto, H., Tatsukawa, T., Yamagata, T., Nakayama, T., Atapour, N., Miura, E., Mazaki, E., Ernst, S J., Cao, D., Ohtani, H., Itohara, S., Yanagawa, Y., Montal, M., Yuzaki, M., Inoue, Y., Hensch, T K., Noebels, J L., Yamakawa, K. Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice. Communications Biology, 2018, DOI: 10.1038/s42003-018-0099-2.


Haginoya, K., Togashi, N., Kaneta, T., Hino-Fukuyo, N., Ishitobi, M., Kakisaka, Y., Uematsu, M., Inui, T., Okubo, Y., Sato, R., Miyabayashi, T., Arai, A., Ogiwara, I., Mazaki, E., Yamakawa, K., Iinuma, K., Kure, S. [18F]fluorodeoxyglucose-positron emission tomography study of genetically confirmed patients with Dravet syndrome. Epilepsy Research, 147: 9-14, 2018, DOI: 10.1016/j.eplepsyres.2018.08.008.

2019年度

Miyamoto, H., Tatsukawa, T., Shimohata, A., Yamagata, T., Suzuki, T., Amano, K., Mazaki, E., Raveau, M., Ogiwara, I., Oba-Asaka, A., Hensch, T.K., Itohara, S., Sakimura, K., Kobayashi, K, Kobayashi, K, Yamakawa, K. Impaired cortico-striatal excitatory transmission triggers epilepsy. Nature Communications, 10: 1917, 2019, DOI: 10.1038/s41467-019-09954-9.

Tatsukawa, T., Raveau, M., Ogiwara, I., Hattori, S., Miyamoto, H., Mazaki, E., Itohara, S., Miyakawa, T., Montal, M., Yamakawa, K. Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity. Molecular Autism, 10: 15, 2019, DOI: 10.1186/s13229-019-0265-5.

2020年度

Ishihara K., Shimizu R., Takata K., Kawashita S., Amano K., Shimohata A., Low D., Nabe T., Sago H., Alexander W.S., Ginhoux F., Yamakawa K., Akiba S. Perturbation of the immune cells and prenatal neurogenesis by the triplication of the Erg gene in mouse models of Down syndrome. Brain Pathology. 30(1):75-91 Jan 2020, DOI: 10.1111/bpa.12758.

Ishii T., Stolz J.R., Swanson G.T. Auxiliary Proteins are the Predominant Determinants of Differential Efficacy of Clinical Candidates Acting as AMPA Receptor Positive Allosteric Modulators. Molecular Pharmacology. 97:336-350 May 2020, DOI: 10.1124/mol.119.118554.

Aoyama J., Homma K., Tanabe N., Usui S., Miyagi Y., Matsuura K., Kaneda M., Nitta T. Spatiotemporal imaging documented the maturation of the cardiomyocytes from human induced pluripotent stem cells. The Journal of Thoracic and Cardiovascular Surgery. 159(6):2260-2271.e7 June 2020, DOI: 10.1016/j.jtcvs.2019.06.060.

Yamagata T., Raveau M., Kobayashi K., Miyamoto H., Tatsukawa T., Ogiwara I., Itohara S., Hensch T. K. Yamakawa K. CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice. Neurobiology of Disease. 141:104954 July 2020, DOI:10.1016/j.nbd.2020.

Suzuki T., Suzuki T., Raveau M., Miyake N., Sudo G., Tsurusaki Y., Watanabe T., Sugaya Y., Tatsukawa T., Mazaki E., Shimohata A., Kushima I., Aleksic B., Shiino T., Tyota T., Iwayama Y., Nakaoka K., Ohmori I., Sasaki A., Watanabe K., Hirose S., Kaneko S., Inoue Y., Yohikawa T., Ozaki N., Kano M., Shimoji T., Matsumoto N., Yamakawa K. A recurrent PJA1 variant in trigonocephaly and neurodevelopmental disorders. Annals of Clinical and Translational Neurology. 7(7):1117-1131 July 2020, DOI: 10.1002/acn3.51093.

Yin C., Ishii T., Kaneda M. Two Types of Cl Transporters Contribute to the Regulation of Intracellular Cl Concentrations in ON- and OFF-type Bipolar Cells in the Mouse Retina. Neuroscience. 1;440:267-276 Aug 2020, DOI:10.1016/j.neuroscience.2020.06.004.

Ishii T., Hosoya T. Interspike intervals within retinal spike bursts combinatorially encode multiple stimulus features. PLOS Computational Biology. 16(11):e1007726 Nov 2020, DOI: 10.1371/journal.pcbi.1007726.

Maneshi M.M., Toth A B., Ishii T., Hori K., Tsujikawa S., Shum A K., Shrestha N., Yamashita M., Miller R.J., Radulovic J., Swanson G.T., Prakriya M. Orai1 Channels Are Essential for Amplification of Glutamate-Evoked Ca2+ Signals in Dendritic Spines to Regulate Working and Associative Memory. Cell Reports. 33(9):108464 Dec 2020, DOI: 10.1016/j.celrep.2020.108464.

2021年度

Dilip R., Akagi T., Shimohata A., Ishii T., Gangi M., Maruyama T., Wada-Kiyama Y., Ogiwara I., Kaneda M. Involvement of the C-terminal domain in cell surface localization and G-protein coupling of mGluR6. Journal of Neurochemistry. 158(4):837-848 Aug 2021, DOI:10.1111/jnc.15217.

2022年度

Maruyama T., Mano A., Ishii T., Kakinuma Y., Kaneda M. P2X2 receptors supply extracellular choline as a substrate for acetylcholine synthesis. FEBS Open Bio. 12(1):250-257 Jan 2022, DOI: 10.1002/2211-5463.13332.