基礎医学

ホーム> 分野（教室）> 基礎医学> 生化学・分子生物学(代謝・栄養学)> 主な発表論文
  1. 1．Nakayama Y, Fujiu K, Yuki R, Oishi Y, Morioka M, Isagawa T, Matsuda J, Oshima T, Matsubara T, Sugita J, Kudo F, Kaneda A, Endo Y, Nakayama T, Nagai R, Komuro I, Manabe I. A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation. Proc Natl Acad Sci USA 2020 in press.
  2. 2．Oishi Y. and Manabe I. “Organ system crosstalk in cardiometabolic disease in the age of multimoribidity. Front Cardiovasc Med 7:64, 2020
  3. 3．Orekhov A, Sukhorukov V, Nikiforov N, Kubekina M, Sobenin I, Foxx K, Pintus S, Stegmaier S, Stelmashenko D, Kel A, Poznyak A,Manabe I, Oishi Y. Signaling Pathways Potentially Responsible for Foam Cell Formation: Cholesterol Accumulation or Inflammatory Response - What is First? Int J Mol Sci, 21, 2716，2020
  4. 4．Orekhov A, Nikiforov N, Sukhorukov V, Kubekina M, Sobenin I, Wu W, Foxx K, Pintus S, Stegmaier P, Stelmashenko D, Kel A, Gratchev A, Melnichenko A, Wetzker R, Summerhill V, Manabe I, Oishi Y. Role of phagocytosis in the pro-inflammatory response in LDL-induced foam cell formation; a transcriptome analysis.　Int J Mol Sci 21(3) 817, 2020
  5. 5．Orekhov AN, Oishi Y, Nikiforov NG, Zhelankin AV, Dubrovsky L, Sobenin IA, Kel A, Stelmashenko D, Makeev VJ, Foxx K, Jin X, Kruth HS, Bukrinsky M. (2018) Modified Ldl Particles Activate Inflammatory Pathways In Monocyte-Derived Macrophages: Transcriptome Analysis. Curr Pharm Des. 25:28.
  6. 6．Orekhov A, Pushkarsky, T, Oishi Y, Nikiforov N, Zhelankin A, Duborovsky L, Makeev V, Foxx K, Jin X, Kruth H, Sobenin I, Sukhorukov V, Burkinsky M.(2018) HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages. Exp Mol Pathol. 105: 202-207.
  7. 7．Oishi Y. and Manabe I.(2018) Macrophages in inflammation, repair and regeneration. International Immunology. 30:511-528.
  8. 8．Oishi Y. and Manabe I.(2018) Kruppel –like factors in metabolic homeostasis and cardiometabolic diseases. Frontiers in cardiovascular medicine. doi: 10:3389/fcvm.2018.00069
  9. 9．Saeki K, Hayakawa S, Nakano S, Ito S, Oishi Y, Suzuki Y, Isemura M. (2018) In vitro and in silico studies of molecular interaction of epigallocatechin-3-O-gallate (EGCG) with proteins that explain the health benefits of green tea. Molecules 23: E1295.
  10. 10．Oishi Y, Spann, NJ, Link VM, Muse ED, Strid T, Edillor C, Kolar MJ, Matsuzaka T, Hayakawa S, Tao J, Kaikkonen M, Lam MT, Manabe I, Shimano H, Saghatelian A and Glass CK. (2017) SREBP1 contributes to resolution of pro-inflammatory TLR4 signaling by reprogramming fatty acid metabolism. Cell Metab. 25: 412-427.
  11. 11．Oishi Y, Hayashi S, Isagawa T, Oshima M, Iwama A, Shimba S, Okamura H and Manabe I. (2017) Bmal1 regulates inflammatory responses in macrophages by modulating enhancer RNA transcription. Sci Rep. 7:7086.
  12. 12．Hayashi S, Manabe I, Suzuki Y, and Oishi Y. (2016) Klf5 regulates muscle differentiation by directly targeting muscle specific genes in cooperation with MyoD in mice. eLife. DOI: http://dx.doi.org/10.7554/eLife.17462.
  13. 13．Lam M, Cho H, Lesch H, Gosselin D, Heinz S, Oishi-Tanaka Y, Benner C, Kaikkonen M, Salim A, Rosenfeld M, Evans R, and Glass CK. (2013) Rev-Erbs negatively regulate macrophage gene expression by repressing enhancer-directed transcription. 498, 511-515.
  14. 14．Eguchi K, Manabe I, Oishi-Tanaka Y, Osugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, and Nagai R. (2012) Saturated fatty acid and TLR signaling link ß cell dysfunction and islet inflammation.  Cell Metab. 15: 518-533.
  15. 15．Oishi Y, Manabe I, Tobe K, Osugi, M, Kubota T, Fujiu K, Maemura K, Kubota N, Kadowaki T, Nagai R. (2008) SUMOylation of KLF5 is a molecular switch regulating PPAR-d-containing transcriptional programs of lipid metabolism. Nat Med. 14: 656-666.
  16. 16. Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, Suzuki R, Kitamura T, Akira S, Kadowaki T, Nagai R. (2005) Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab. 1:27-39.

    ＜岩崎俊男 講師グループ＞

    1． Geldenhuys, W. J.,* Long, T. E., Saralkar, P., Iwasaki, T., Nuñez, R. A. A., Nair, R. R., Konkle, M. E., Menze, M. A., Pinti, M. V., Hollander, J. M., Hazlehurst, L. A., and Robart, A. R.* (2019) Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand. Communications Chemistry 2, Article number: 77.

    2． Taguchi, A. T.,* Ohmori, D., Dikanov, S. A., and Iwasaki, T.* (2018) g-Tensor directions in the protein structural frame of hyperthermophilic archaeal reduced Rieske-type ferredoxin explored by 13C pulsed electron paramagnetic resonance. Biochemistry 47, 4074-4082.

    3． Taguchi, A. T., Miyajima-Nakano, Y., Fukazawa, R., Lin, M. T., Baldansuren, A., Gennis, R. B., Hasegawa, K., Kumasaka, T., Dikanov, S. A.,* and Iwasaki, T.* (2018) Unpaired electron spin density distribution across reduced [2Fe-2S] cluster ligands by 13Cβ-cysteine labeling. Inorg. Chem. 57, 741-746.

    4． Lin, M. T., Fukazawa, R., Miyajima-Nakano, Y., Matsushita, S., Choi, S. K., Iwasaki, T.,* and Gennis, R. B. (2015) Escherichia coli auxotroph host strains for amino acid-selective isotope labeling of recombinant proteins. Methods Enzymol. 565, 45-66.

    5． Iwasaki, T.,* Fukazawa, R., Miyajima-Nakano, Y., Baldansuren, A., Matsushita, S., Lin, M. T., Gennis, R. B., Hasegawa, K., Kumasaka, T., and Dikanov, S. A.* (2012) Dissection of hydrogen bond interaction network around an iron-sulfur cluster by site-specific isotope labeling of hyperthermophilic archaeal Rieske-type ferredoxin. J. Am. Chem. Soc. 134, 19731-19738.

    6． Iwasaki, T.,* Samoilova, R. I., Kounosu, A., Ohmori, D., and Dikanov, S. A.* (2009) Continuous-wave and pulsed EPR characterization of the [2Fe-2S](Cys)3(His)1 cluster in rat mitoNEET. J. Am. Chem. Soc. 131, 13659-13667.

    ＜小池博之 助教＞

    1． Koike H, Iwasawa K, Ouchi R, Maezawa M, Giesbrecht K, Saiki N, Ferguson A, Kimura M, Thompson W.L., Wells J.M., Zorn A.M., Takebe T. “Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary.” Nature, 574, 112-116, 2019

    2． Ouchi R., Togo S., Kimura M., Shinozawa T., Koido M., Koike H., Thompson W., Karns R.A., Mayhew C.N., McGrath P.S., McCauley H.A., Zhang R.R., Lewis K., Hakozaki S., Ferguson A., Saiki N., Yoneyama Y., Takeuchi I., Mabuchi Y., Akazawa C., Yoshikawa H.Y., Wells J.M., Takebe T. “Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids.” Cell Metabolism, 30, 2, 374-384, 2019

    3． Koike H., Zhang R.R., Ueno Y., Sekine K., Zheng Y.W., Takebe T, Taniguchi H. “Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism.” Development, 144, 6, 1018-1024, 2017